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What if there is blood inside the crime left by the offenders?

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The CSI that comes to your crime scene will be careful that they do not contaminate the blood so will put on a pair of gloves and a face mask before recovering the sample. This can either be done swabbing the blood, or any other DNA source the CSI may see. If the blood is on an object such as paper etc, they may recover that item and leave the blood on it.